Incidence of dementia after age 90 in a multiracial cohort.
Dementia
Disparities
Epidemiology
Ethnicity
Oldest-old
Race
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
08
2018
revised:
03
12
2018
accepted:
11
12
2018
pubmed:
25
2
2019
medline:
28
4
2020
entrez:
25
2
2019
Statut:
ppublish
Résumé
Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life. Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.
Identifiants
pubmed: 30797730
pii: S1552-5260(18)33623-9
doi: 10.1016/j.jalz.2018.12.006
pmc: PMC6497045
mid: NIHMS1521216
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-505Subventions
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG053410
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056519
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049663
Pays : United States
Informations de copyright
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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