Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?
Domestication
Evolution
Gene loss
Genome
GnIH
Kisspeptin
Synteny
Zebrafish
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
27
11
2018
revised:
12
02
2019
accepted:
14
02
2019
pubmed:
25
2
2019
medline:
3
1
2020
entrez:
25
2
2019
Statut:
ppublish
Résumé
Gonadotropin releasing hormone (GnRH) is a highly conserved neuroendocrine decapeptide that is essential for the onset of puberty and the maintenance of the reproductive state. First identified in mammals, the GnRH signaling pathway is found in all classes of vertebrates; homologues of GnRH have also been identified in invertebrates. In addition to its role as a hypothalamic releasing hormone, GnRH has multiple functions including modulating neural activity within specific regions of the brain. These various functions are mediated by multiple isoforms, which are expressed at diverse locations within the central nervous system. Here we discuss the GnRH signaling pathways in light of new reports that reveal that some vertebrate genomes lack GnRH1. Not only do other isoforms of GnRH not compensate for this gene loss, but elements upstream of GnRH1, including kisspeptins, appear to also be dispensable. We discuss routes that may compensate for the loss of the GnRH1 pathway.
Identifiants
pubmed: 30797802
pii: S0091-3022(19)30008-1
doi: 10.1016/j.yfrne.2019.02.002
pmc: PMC7216701
mid: NIHMS1585553
pii:
doi:
Substances chimiques
Kisspeptins
0
Gonadotropin-Releasing Hormone
33515-09-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100738Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM085318
Pays : United States
Organisme : NIH HHS
ID : R01 OD011116
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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