Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan.
Journal
Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
29
07
2018
revised:
12
01
2019
accepted:
14
02
2019
pubmed:
25
2
2019
medline:
5
6
2019
entrez:
25
2
2019
Statut:
ppublish
Résumé
Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life.
Identifiants
pubmed: 30797900
pii: S0041-0101(19)30051-0
doi: 10.1016/j.toxicon.2019.02.010
pii:
doi:
Substances chimiques
Antivenins
0
Snake Venoms
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-58Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.