Generation of a human induced pluripotent stem cell line (MUi010-A) from skin fibroblast of patient carrying a c.2104C>T mutation in MYH9 gene.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
04
01
2019
accepted:
26
01
2019
pubmed:
25
2
2019
medline:
11
4
2020
entrez:
25
2
2019
Statut:
ppublish
Résumé
Mutations in MYH9 gene is one of the major causes of inherited thrombocytopenia resulted from nonfunctional myosin-9 protein. We have generated a human induced pluripotent stem cell line MUi010-A from skin fibroblasts of a patient who had a point mutation c.2104C>T (p.R702C) in the exon 16 of MYH9 gene using a non-integrative reprogramming method. The MUi010-A exhibited embryonic stem cell-like characteristics with consistent pluripotent markers expression, was capable of all three embryonic germ layers differentiation, and had a normal karyotype.
Identifiants
pubmed: 30798146
pii: S1873-5061(19)30027-3
doi: 10.1016/j.scr.2019.101397
pii:
doi:
Substances chimiques
MYH9 protein, human
0
Myosin Heavy Chains
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101397Informations de copyright
Copyright © 2019. Published by Elsevier B.V.