HIV Retesting of HIV-Negative Pregnant Women in the Context of Prevention of Mother-to-Child Transmission of HIV in Primary Health Centers in Rural Zambia: What Did We Learn?
Adolescent
Adult
Child
Early Diagnosis
Female
HIV Infections
/ diagnosis
HIV Seropositivity
Humans
Infectious Disease Transmission, Vertical
/ prevention & control
Mass Screening
Middle Aged
Mothers
Pregnancy
Pregnancy Complications, Infectious
/ prevention & control
Prenatal Care
Primary Health Care
/ statistics & numerical data
Qualitative Research
Rural Population
Young Adult
Zambia
HIV testing and counseling
Zambia
prevention of mother-to-child transmission
Journal
Journal of the International Association of Providers of AIDS Care
ISSN: 2325-9582
Titre abrégé: J Int Assoc Provid AIDS Care
Pays: United States
ID NLM: 101603896
Informations de publication
Date de publication:
Historique:
entrez:
26
2
2019
pubmed:
26
2
2019
medline:
22
4
2020
Statut:
ppublish
Résumé
This observational study describes implementation of HIV retesting of HIV-negative women in prevention of mother-to-child transmission (PMTCT) services in Zambia. Uptake of retesting and PMTCT services were compared across age, parity, and weeks of gestation at the time of the first HIV test, antiretrovirals regime, and HIV early diagnosis results from infants born to HIV-positive mothers. A total of 19 090 pregnant women were tested for HIV at their first antenatal visit, 16 838 tested HIV-negative and were offered retesting 3 months later: 11 339 (67.3%) were retested; of those, 55 (0.5%) were HIV positive. Uptake of the PMTCT package by women HIV positive at retest was not different but HIV-exposed infants born to women who retested HIV positive were infected at a higher rate (11.1%) compared to those born to women who tested HIV positive at their initial test (3.2%). We suggest rigorously (1) measuring the proportion of MTCT attributable to women who seroconvert during pregnancy and possibly adjust PMTCT approaches and (2) addressing the substantial loss to follow-up of HIV-negative pregnant women before HIV retesting.
Sections du résumé
BACKGROUND
This observational study describes implementation of HIV retesting of HIV-negative women in prevention of mother-to-child transmission (PMTCT) services in Zambia.
METHODS
Uptake of retesting and PMTCT services were compared across age, parity, and weeks of gestation at the time of the first HIV test, antiretrovirals regime, and HIV early diagnosis results from infants born to HIV-positive mothers.
RESULTS
A total of 19 090 pregnant women were tested for HIV at their first antenatal visit, 16 838 tested HIV-negative and were offered retesting 3 months later: 11 339 (67.3%) were retested; of those, 55 (0.5%) were HIV positive. Uptake of the PMTCT package by women HIV positive at retest was not different but HIV-exposed infants born to women who retested HIV positive were infected at a higher rate (11.1%) compared to those born to women who tested HIV positive at their initial test (3.2%).
CONCLUSION
We suggest rigorously (1) measuring the proportion of MTCT attributable to women who seroconvert during pregnancy and possibly adjust PMTCT approaches and (2) addressing the substantial loss to follow-up of HIV-negative pregnant women before HIV retesting.
Identifiants
pubmed: 30798664
doi: 10.1177/2325958218823530
pmc: PMC6748466
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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