Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase-2 Activation in Copper/Zinc Superoxide Dismutase-Deficient Mice.
Animals
Atrophy
/ genetics
Biopsy, Needle
Blotting, Western
/ methods
Copper
/ deficiency
Forkhead Box Protein O3
/ genetics
Furans
/ pharmacology
Immunohistochemistry
Lignans
/ pharmacology
Matrix Metalloproteinase 2
/ metabolism
Mice
Mice, Hairless
Polymerase Chain Reaction
/ methods
Skin Aging
/ drug effects
Superoxide Dismutase
/ deficiency
Superoxide Dismutase-1
/ genetics
Treatment Outcome
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
02
07
2018
revised:
30
09
2018
accepted:
16
10
2018
entrez:
26
2
2019
pubmed:
26
2
2019
medline:
26
2
2020
Statut:
ppublish
Résumé
Aging is characterized by accumulation of chronic and irreversible oxidative damage, chronic inflammation, and organ dysfunction. Superoxide dismutase (SOD) serves as a major enzyme for cellular superoxide radical metabolism and physiologically regulates cellular redox balance throughout the body. Copper/zinc superoxide dismutase-deficient (SOD1
Identifiants
pubmed: 30798853
pii: S0022-202X(18)32703-9
doi: 10.1016/j.jid.2018.10.012
pii:
doi:
Substances chimiques
Forkhead Box Protein O3
0
FoxO3 protein, mouse
0
Furans
0
Lignans
0
syringaresinol
21453-69-0
Copper
789U1901C5
Sod1 protein, mouse
EC 1.15.1.1
Superoxide Dismutase
EC 1.15.1.1
Superoxide Dismutase-1
EC 1.15.1.1
Matrix Metalloproteinase 2
EC 3.4.24.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-655Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.