DNA repair by photolyases.

Cryptochromes / chemistry DNA Repair Deoxyribodipyrimidine Photo-Lyase / chemistry Humans
Blue light DNA damage DNA repair Photolyase Reaction mechanism

Journal

Advances in protein chemistry and structural biology
ISSN: 1876-1631
Titre abrégé: Adv Protein Chem Struct Biol
Pays: Netherlands
ID NLM: 101497281

Informations de publication

Date de publication:
2019
Historique:
entrez: 26 2 2019
pubmed: 26 2 2019
medline: 21 12 2019
Statut: ppublish

Résumé

Photolyases belong to the cryptochrome/photolyase protein family (CPF) which perform different functions such as DNA repair, circadian photoreceptor, and transcriptional regulation. Photolyase is a flavoprotein that repairs UV-induced DNA damages of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproducts using blue-light as an energy source. This enzyme has two chromophores: flavin adenine dinucleotide (FAD) as a cofactor and a photoantenna such as methenyltetrahydrofolate (MTHF). The FAD is essential for catalysis of the DNA repair. The second chromophore absorbs photons from the blue light spectrum and transfers energy to FAD to increase the repair efficiency of the enzyme. Phylogenetic analysis in which amino acid sequences of several hundreds of CPF members are used suggests that they form more classes than we have considered so far. In this chapter, we discussed structure-functions and reaction mechanisms of different classes of photolyases.

Identifiants

DOI: 10.1016/bs.apcsb.2018.10.003 PMID: 30798929
pubmed: 30798929
pii: S1876-1623(18)30065-8
doi: 10.1016/bs.apcsb.2018.10.003
pii:
doi:

Substances chimiques

Cryptochromes 0
Deoxyribodipyrimidine Photo-Lyase EC 4.1.99.3

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-19

Informations de copyright

© 2019 Elsevier Inc. All rights reserved.

Auteurs

Ibrahim Halil Kavakli (IH)

Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey. Electronic address: hkavakli@ku.edu.tr.

Nuri Ozturk (N)

Department of Molecular Biology and Genetics, Gebze Technical University, Kocaeli, Turkey.

Seref Gul (S)

Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Photorécepteurs végétaux › Cryptochromes › DNA repair by photolyases.
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › DNA repair by photolyases.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-carbon lyases › Deoxyribodipyrimidine photo-lyase › DNA repair by photolyases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA repair by photolyases.