Endocardially Derived Macrophages Are Essential for Valvular Remodeling.

Animals Embryo, Mammalian / metabolism Endocardium / metabolism Gene Expression Regulation, Developmental / physiology Heart Valves / cytology Hematopoiesis / physiology Macrophages / metabolism Mesoderm / metabolism Mice, Transgenic NFATC Transcription Factors / metabolism Yolk Sac
cardiac tissue macrophage cardiogenesis congenital heart disease hematopoiesis hemogenic endocardium multipotent cardiac progenitor cells tissue macrophages valve disease valve remodeling valvulogenesis

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
11 03 2019
Historique:
received: 05 09 2018
revised: 06 12 2018
accepted: 22 01 2019
pubmed: 26 2 2019
medline: 29 8 2019
entrez: 26 2 2019
Statut: ppublish

Résumé

During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered question is whether these local transient hematopoietic mechanisms are essential for embryonic growth. Here, we show that endocardial hematopoiesis is critical for cardiac valve remodeling as a source of tissue macrophages. Colony formation assay from explanted heart tubes and genetic lineage tracing with the endocardial specific Nfatc1-Cre mouse revealed that hemogenic endocardium is a de novo source of tissue macrophages in the endocardial cushion, the primordium of the cardiac valves. Surface marker characterization, gene expression profiling, and ex vivo phagocytosis assay revealed that the endocardially derived cardiac tissue macrophages play a phagocytic and antigen presenting role. Indeed, genetic ablation of endocardially derived macrophages caused severe valve malformation. Together, these data suggest that transient hemogenic activity in the endocardium is indispensable for the valvular tissue remodeling in the heart.

Identifiants

DOI: 10.1016/j.devcel.2019.01.021 PMID: 30799229 PMC: PMC6440481
pubmed: 30799229
pii: S1534-5807(19)30049-8
doi: 10.1016/j.devcel.2019.01.021
pmc: PMC6440481
mid: NIHMS1519567
pii:
doi:

Substances chimiques

NFATC Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

617-630.e3

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL129727
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM055052
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075867
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118650
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127427
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111437
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137241
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129178
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Ayako Shigeta (A)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Vincent Huang (V)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Jonathan Zuo (J)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Rana Besada (R)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Yasuhiro Nakashima (Y)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Yan Lu (Y)

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Yichen Ding (Y)

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Matteo Pellegrini (M)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Rajan P Kulkarni (RP)

Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Tzung Hsiai (T)

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Arjun Deb (A)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Bin Zhou (B)

Department of Genetics, Pediatrics, and Medicine (Cardiology), Albert Einstein College of Medicine, New York, NY 10461, USA.

Haruko Nakano (H)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Atsushi Nakano (A)

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: anakano@ucla.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Endocarde › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription NFATC › Endocardially Derived Macrophages Are...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Vésicule vitelline › Endocardially Derived Macrophages Are...