Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated with Different Habitual Diets.
Western population
human microbiome
metagenomics
non-Western population
omnivore diet
vegan diet
vegetarian diet
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
13 Mar 2019
13 Mar 2019
Historique:
received:
15
01
2018
revised:
14
11
2018
accepted:
08
01
2019
pubmed:
26
2
2019
medline:
9
11
2019
entrez:
26
2
2019
Statut:
ppublish
Résumé
The role of intestinal Prevotella species in human health is controversial, with both positive and negative associations. Strain-level diversity may contribute to discrepancies in genus and species associations with health and disease. We dissected the gut metagenomes of Italians with varying dietary habits, investigating the presence of distinct Prevotella copri strains. Fiber-rich diets were linked to P. copri types with enhanced potential for carbohydrate catabolism. P. copri strains associated with an omnivore diet had a higher prevalence of the leuB gene-involved in branched-chain amino acid biosynthesis-a risk factor for glucose intolerance and type 2 diabetes. These P. copri pangenomes were compared to existing cohorts, providing evidence of distinct gene repertoires characterizing different P. copri populations, with drug metabolism and complex carbohydrate degradation significantly associated with Western and non-Western individuals, respectively. Strain-level P. copri diversity in gut microbiomes is affected by diet and should be considered when examining host-microbe associations.
Identifiants
pubmed: 30799264
pii: S1931-3128(19)30041-1
doi: 10.1016/j.chom.2019.01.004
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
444-453.e3Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.