Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats.
Cisplatin
Oxidative stress
Spermatogenesis
Testis
Vitamin A
Journal
The world journal of men's health
ISSN: 2287-4208
Titre abrégé: World J Mens Health
Pays: Korea (South)
ID NLM: 101596899
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
11
2018
revised:
15
12
2018
accepted:
27
12
2018
pubmed:
26
2
2019
medline:
26
2
2019
entrez:
26
2
2019
Statut:
ppublish
Résumé
To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.
Identifiants
pubmed: 30799561
pii: 37.e5
doi: 10.5534/wjmh.180105
pmc: PMC6479087
doi:
Types de publication
Journal Article
Langues
eng
Pagination
249-256Informations de copyright
Copyright © 2019 Korean Society for Sexual Medicine and Andrology.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
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