Male Inflammatory Parameters Are not Useful to Predict the Outcomes of Intracytoplasmic Sperm Injection: Results from a Cross-Sectional Study.
Assisted reproductive techniques
Fertilization
Infertility
Inflammation
Semen analysis
Sperm injections, intracytoplasmic
Journal
The world journal of men's health
ISSN: 2287-4208
Titre abrégé: World J Mens Health
Pays: Korea (South)
ID NLM: 101596899
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
22
11
2018
revised:
19
12
2018
accepted:
09
01
2019
pubmed:
26
2
2019
medline:
26
2
2019
entrez:
26
2
2019
Statut:
ppublish
Résumé
The relationship between male systemic inflammation and fertility seems intriguing, but no data about its impact on the assisted reproductive technology outcomes has been reported. Here, we aimed to evaluate the prognostic role of male systemic inflammatory parameters in intracytoplasmic sperm injection (ICSI) outcomes prediction, in couples undergoing an ovum donation program. From January 2016 to December 2017, one hundred-ten couples were considered for this cross-sectional study. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-eosinophil ratio (MER), platelet-to-lymphocyte ratio (PLR), seminal parameters, fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR) were evaluated. Male patients were divided into Group A with FR ≤70%, Group B with FR >70%. Overall, FR was 74.5%, CR 90.9%, PR 41.8%. Group A included 43 patients, Group B 67 men. Group A showed a median NLR of 1.55, PLR of 106.09, MER of 2.33. Group B reported a median NLR of 1.64, PLR 109.0, MER 2.76. We found no statistically differences between two groups with respect to NLR, PLR, MER (p=0.90, p=0.70, p=0.96, respectively). The age-adjusted linear regression analysis demonstrated only a relationship between NLR and sperm motility count (r=-0.02; p<0.05). Using the univariate logistic regression analysis, we found no significant associations. We did not find any relationship between ICSI outcomes and male inflammation parameters.
Identifiants
pubmed: 30799563
pii: 37.e7
doi: 10.5534/wjmh.180110
pmc: PMC6704309
doi:
Types de publication
Journal Article
Langues
eng
Pagination
347-354Informations de copyright
Copyright © 2019 Korean Society for Sexual Medicine and Andrology.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
Références
Bratisl Lek Listy. 2001;102(1):5-14
pubmed: 11723675
J Reprod Immunol. 2002 Oct-Nov;57(1-2):3-18
pubmed: 12385830
Urol Int. 2006;76(2):122-5
pubmed: 16493211
Reprod Biomed Online. 2007 Jun;14(6):727-33
pubmed: 17579989
Reprod Biomed Online. 2008 Nov;17(5):628-31
pubmed: 18983746
Fertil Steril. 2009 Nov;92(5):1772-5
pubmed: 19539905
Reprod Biomed Online. 2010 Jun;20(6):848-56
pubmed: 20378414
PLoS One. 2011;6(9):e25295
pubmed: 21966488
Int Arch Med. 2012 Jan 26;5(1):2
pubmed: 22281066
Reprod Biomed Online. 2012 Aug;25(2):146-67
pubmed: 22727888
Clin Appl Thromb Hemost. 2014 Jan;20(1):50-4
pubmed: 22790659
J Surg Oncol. 2013 Apr;107(5):493-7
pubmed: 22996403
Int Braz J Urol. 2012 Sep-Oct;38(5):576-94
pubmed: 23131516
J Clin Lab Anal. 2013 Jan;27(1):72-6
pubmed: 23292894
Urology. 2013 May;81(5):962-6
pubmed: 23465534
Ann Lab Med. 2013 Mar;33(2):105-10
pubmed: 23482854
Clin Exp Hypertens. 2014;36(4):217-21
pubmed: 23786430
Sci Rep. 2014 Mar 03;4:4260
pubmed: 24584780
Parasitology. 2014 Sep;141(11):1489-98
pubmed: 24721985
Menopause. 2015 Sep;22(9):1000-5
pubmed: 25647778
J Reprod Immunol. 2015 Apr;108:98-104
pubmed: 25796532
Andrologia. 2016 Aug;48(6):626-30
pubmed: 26437740
J Reprod Infertil. 2015 Jul-Sep;16(3):123-9
pubmed: 26913230
Eur J Rheumatol. 2015 Mar;2(1):20-23
pubmed: 27708915
Korean J Ophthalmol. 2016 Oct;30(5):377-381
pubmed: 27729758
World J Mens Health. 2017 Apr;35(1):51-56
pubmed: 28459146
Reprod Biomed Online. 2017 Nov;35(5):494-510
pubmed: 28784335
Ocul Immunol Inflamm. 2018;26(8):1219-1222
pubmed: 28910561
Andrology. 2017 Nov;5(6):1100-1104
pubmed: 28992369