Genetic risk factors for eating disorders: an update and insights into pathophysiology.
GWAS
anorexia nervosa
binge-eating disorder
bulimia nervosa
genetics
microbiome
Journal
Therapeutic advances in psychopharmacology
ISSN: 2045-1253
Titre abrégé: Ther Adv Psychopharmacol
Pays: England
ID NLM: 101555693
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
06
2018
accepted:
15
10
2018
entrez:
26
2
2019
pubmed:
26
2
2019
medline:
26
2
2019
Statut:
epublish
Résumé
Genome-wide-association studies (GWASs), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and binge-eating disorder are relatively scarce, with the exception of a few formal genetic and small-sized candidate-gene-association studies. In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.
Identifiants
pubmed: 30800283
doi: 10.1177/2045125318814734
pii: 10.1177_2045125318814734
pmc: PMC6378634
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2045125318814734Déclaration de conflit d'intérêts
Conflict of interest statement: Janet Treasure declares that she will be the Principal Investigator of a randomized controlled trial evaluating the effects of naloxone hydrochloride nasal spray on eating behaviours in bulimia nervosa sponsored by Opiant Pharmaceuticals. All other authors declare no conflict of interest.
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