Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Feb 2019
01 Feb 2019
Historique:
received:
08
11
2018
revised:
19
12
2018
accepted:
19
12
2018
entrez:
26
2
2019
pubmed:
26
2
2019
medline:
26
2
2019
Statut:
epublish
Résumé
Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented deformable mirror (DM) to introduce minor perturbations in the point spread function. This approach creates uncorrelated speckle patterns in a series of images, enabling averaging to suppress speckle noise while maintaining structural detail. A method is presented that efficiently determines the optimal range of modulation of DM segments relative to their AO-optimized position so that speckle noise is reduced while image resolution and signal strength are preserved. The method is active and independent of sample properties. Its effectiveness and efficiency are quantified and demonstrated by both
Identifiants
pubmed: 30800499
doi: 10.1364/BOE.10.000552
pii: 351209
pmc: PMC6377907
doi:
Types de publication
Journal Article
Langues
eng
Pagination
552-570Subventions
Organisme : NEI NIH HHS
ID : P30 EY012576
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY002660
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026556
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY015387
Pays : United States
Déclaration de conflit d'intérêts
R.J.Z, E.N.P and P. Z are listed as inventors on a patent application related to the work presented in this manuscript.
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