MicroRNAs are Critical Regulators of Osteoclast Differentiation.
Osteoclast
differentiation
fusion
miRNA
microarray
noncoding RNA
Journal
Current molecular biology reports
ISSN: 2198-6428
Titre abrégé: Curr Mol Biol Rep
Pays: Switzerland
ID NLM: 101652149
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
26
2
2019
pubmed:
26
2
2019
medline:
26
2
2019
Statut:
ppublish
Résumé
Our goal is to comprehensively review the most recent reports of microRNA (miRNA) regulation of osteoclastogenesis. We highlight validated miRNA-target interactions and their place in the signaling networks controlling osteoclast differentiation and function. Using unbiased approaches to identify miRNAs of interest and reporter-3'UTR assays to validate interactions, recent studies have elucidated the impact of specific miRNA-mRNA interactions during in vitro osteoclastogenesis. There has been a focus on signaling mediators downstream of the RANK and CSF1R signaling, and genes essential for differentiation and function. For example, several miRNAs directly and indirectly target the master osteoclast transcription factor, Nfatc1 (e.g. miR-124 and miR-214) and Rho-GTPases, Cdc42 and Rac1 (e.g. miR-29 family). Validating miRNA expression patterns, targets, and impact in osteoclasts and other skeletal cells is critical for understanding basic bone biology and for fulfilling the therapeutic potential of miRNA-based strategies in the treatment bone diseases.
Identifiants
pubmed: 30800633
doi: 10.1007/s40610-019-0116-3
pmc: PMC6380495
mid: NIHMS1518889
doi:
Types de publication
Journal Article
Langues
eng
Pagination
65-74Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR064867
Pays : United States
Organisme : NIDCR NIH HHS
ID : T90 DE021989
Pays : United States
Organisme : NIDCR NIH HHS
ID : T90 DE033006
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Henry C. Hrdlicka, Sun-Kyeong Lee, and Anne M. Delany each declare no potential conflicts of interest.
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