The carcinogenic potential of non-ionizing radiations: The cases of S-50 Hz MF and 1.8 GHz GSM radiofrequency radiation.
Animals
Carcinogenesis
/ radiation effects
Disease Models, Animal
Electromagnetic Fields
/ adverse effects
Environmental Exposure
/ adverse effects
Female
Humans
Incidence
Neoplasms
/ epidemiology
Pregnancy
Prenatal Exposure Delayed Effects
/ epidemiology
Radiation, Nonionizing
/ adverse effects
Rats, Sprague-Dawley
Sprague Dawley rats
cancer promotion
carcinogenicity
co-carcinogenesis
extremely low-frequency magnetic fields
mobile phone
radiofrequency radiation
schwannoma
Journal
Basic & clinical pharmacology & toxicology
ISSN: 1742-7843
Titre abrégé: Basic Clin Pharmacol Toxicol
Pays: England
ID NLM: 101208422
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
23
11
2018
accepted:
14
02
2019
pubmed:
26
2
2019
medline:
28
1
2020
entrez:
26
2
2019
Statut:
ppublish
Résumé
Epidemiological studies have suggested that human exposure to extremely low-frequency electromagnetic fields from the electric power and to mobile phone radiofrequency electromagnetic fields induce an increased risk of developing malignant tumours. However, no adequate laboratory data, in particular long-term carcinogenicity bioassays to support the epidemiological evidence, have yet been available. This motivated the Ramazzini Institute to embark on a first project of four large life-span carcinogenic bioassays conducted on over 7000 Sprague Dawley rats exposed from prenatal life until natural death to S-50 Hz MF alone or combined with gamma radiation or formaldehyde or aflatoxin B1. Results now available from these studies, which started concurrently, have shown that exposure to Sinusoidal-50 Hz Magnetic Field (S-50 Hz MF) combined with acute exposure to gamma radiation or to chronic administration of formaldehyde in drinking water induces a significantly increased incidence of malignant tumours in males and females. A second project of two large life-span carcinogenic bioassays was conducted on over 3000 Sprague Dawley rats exposed from prenatal life until natural death to 1.8 GHz GSM of mobile phone radio base station, alone or combined with acute exposure to gamma radiation. Early results from the experiment on 1.8 GHz GSM alone show a statistically significant increase in the incidence of heart malignant schwannoma among males exposed at the highest dose.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-69Informations de copyright
© 2019 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
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