Extent of Inflammation and Foreign Body Reaction to Porous Polyethylene

Animals Biocompatible Materials / administration & dosage Cytokines / genetics Foreign-Body Reaction / chemically induced Gene Expression Regulation / drug effects Inflammation / chemically induced Mice Mice, Inbred BALB C Polyethylene / administration & dosage Porosity / drug effects Prostheses and Implants / adverse effects RAW 264.7 Cells Tumor Necrosis Factor-alpha / genetics
Polyethylenes biomaterials cytokines foreign-body reaction macrophages

Journal

In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809

Informations de publication

Date de publication:
Historique:
received: 06 12 2018
revised: 14 12 2018
accepted: 17 12 2018
entrez: 27 2 2019
pubmed: 26 2 2019
medline: 6 6 2019
Statut: ppublish

Résumé

High-density porous polyethylene (PP) offers possibilities for reconstruction in craniofacial surgery. The purpose of this study was to evaluate the extent of inflammation and foreign body reactions to PP in vitro and in vivo. Cell attachment, proliferation and expression of inflammatory cytokines were assessed using murine macrophages (RAW 264.7) on two different PP materials in vitro. In vivo, Balb/c mice received PP implants at their dorsum. After sacrifice, samples were analyzed histologically and real-time PCR was used to assess expression of inflammatory cytokines. Cells showed a significantly decreased proliferation (p<0.001) after 48 h and a significantly increased expression of TNF-α (p<0.05) at 24, 48 and 72 h. All animals showed foreign body cell reactions and signs of chronic inflammation. Expression of all but one of the investigated cytokines dropped to non-significant levels after an initial increase. Application of porous polyethylene can cause local chronic inflammatory reactions. Although clinical application seems to be immunologically safe, indication and risks should be evaluated carefully when using PP implants.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
High-density porous polyethylene (PP) offers possibilities for reconstruction in craniofacial surgery. The purpose of this study was to evaluate the extent of inflammation and foreign body reactions to PP in vitro and in vivo.
MATERIALS AND METHODS METHODS
Cell attachment, proliferation and expression of inflammatory cytokines were assessed using murine macrophages (RAW 264.7) on two different PP materials in vitro. In vivo, Balb/c mice received PP implants at their dorsum. After sacrifice, samples were analyzed histologically and real-time PCR was used to assess expression of inflammatory cytokines.
RESULTS RESULTS
Cells showed a significantly decreased proliferation (p<0.001) after 48 h and a significantly increased expression of TNF-α (p<0.05) at 24, 48 and 72 h. All animals showed foreign body cell reactions and signs of chronic inflammation. Expression of all but one of the investigated cytokines dropped to non-significant levels after an initial increase.
CONCLUSION CONCLUSIONS
Application of porous polyethylene can cause local chronic inflammatory reactions. Although clinical application seems to be immunologically safe, indication and risks should be evaluated carefully when using PP implants.

Identifiants

DOI: 10.21873/invivo.11479 PMID: 30804110 PMC: PMC6506308
pubmed: 30804110
pii: 33/2/337
doi: 10.21873/invivo.11479
pmc: PMC6506308
doi:

Substances chimiques

Biocompatible Materials 0
Cytokines 0
Tumor Necrosis Factor-alpha 0
Polyethylene 9002-88-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

337-347

Informations de copyright

Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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Auteurs

Tobias Vollkommer (T)

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Anders Henningsen (A)

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany a.henningsen@uke.de.
Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Oral and Maxillofacial Surgery, German Armed Forces Hospital, Hamburg, Germany.

Reinhard E Friedrich (RE)

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Oliver Heinrich Felthaus (OH)

Department of Plastic, Hand and Restoration Surgery, Caritas Hospital St. Josef, Regensburg, Germany.

Fabian Eder (F)

Private practice, Regensburg, Germany.

Christian Morsczeck (C)

Department of Oral and Maxillofacial Surgery, University Medical Center-Regensburg, Regensburg, Germany.

Ralf Smeets (R)

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Sebastian Gehmert (S)

Department of Orthopaedics, University Children's Hospital Basel, Basel, Switzerland.

Martin Gosau (M)

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Plaies et blessures › Corps étrangers › Réaction à corps étranger › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyéthylènes › Polyéthylène › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Porosité › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Extent of Inflammation and Foreign Body...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Extent of Inflammation and Foreign Body...