Validation of clinic-based cryptococcal antigen lateral flow assay screening in HIV-infected adults in South Africa.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 02 2019
25 02 2019
Historique:
received:
04
09
2018
accepted:
06
12
2018
entrez:
27
2
2019
pubmed:
26
2
2019
medline:
15
9
2020
Statut:
epublish
Résumé
Since rapid cryptococcal antigen lateral flow assays (CrAg LFA) may expedite treatment of HIV-associated cryptococcal infections, we sought to validate clinic-based CrAg LFA testing. Among newly-diagnosed HIV-infected adults in South Africa, a trained nurse performed clinic-based testing of urine, fingerprick capillary and venous whole blood with rapid CrAg LFA (Immy Diagnostics, Norman, USA). We performed matched laboratory-based serum cryptococcal antigen testing with an enzyme immunoassay (EIA). We assessed diagnostic accuracy using EIA as the gold-standard, and performed additional validation testing on serum and among hospitalized adults with cryptococcal meningitis. Among 5,618 participants enrolled, 1,296 were HIV-infected and screened for cryptococcal antigenemia. Overall CrAg prevalence by serum EIA was 3.6% (95% CI 2.0-6.0%) for adults with CD4 < 200 cells/mm
Identifiants
pubmed: 30804356
doi: 10.1038/s41598-018-37478-7
pii: 10.1038/s41598-018-37478-7
pmc: PMC6389876
doi:
Substances chimiques
Antigens, Fungal
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2687Subventions
Organisme : NIAID NIH HHS
ID : K23 AI108293
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI060354
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI110264
Pays : United States
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