Accessing analytes in biofluids for peripheral biochemical monitoring.


Journal

Nature biotechnology
ISSN: 1546-1696
Titre abrégé: Nat Biotechnol
Pays: United States
ID NLM: 9604648

Informations de publication

Date de publication:
04 2019
Historique:
received: 09 03 2018
accepted: 20 11 2018
pubmed: 26 2 2019
medline: 24 4 2019
entrez: 27 2 2019
Statut: ppublish

Résumé

Peripheral biochemical monitoring involves the use of wearable devices for minimally invasive or noninvasive measurement of analytes in biofluids such as interstitial fluid, saliva, tears and sweat. The goal in most cases is to obtain measurements that serve as surrogates for circulating analyte concentrations in blood. Key technological developments to date include continuous glucose monitors, which use an indwelling sensor needle to measure glucose in interstitial fluid, and device-integrated sweat stimulation for continuous access to analytes in sweat. Further development of continuous sensing technologies through new electrochemical sensing modalities will be a major focus of future research. While there has been much investment in wearable technologies to sense analytes, less effort has been directed to understanding the physiology of biofluid secretion. Elucidating the underlying biology is crucial for accelerating technological progress, as the biofluid itself often presents the greatest challenge in terms of sample volumes, secretion rates, filtration, active analyte channels, variable pH and salinity, analyte breakdown and other confounding factors.

Identifiants

pubmed: 30804536
doi: 10.1038/s41587-019-0040-3
pii: 10.1038/s41587-019-0040-3
doi:

Substances chimiques

Blood Glucose 0
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

407-419

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Auteurs

Jason Heikenfeld (J)

Novel Devices Laboratory, University of Cincinnati, Cincinnati, Ohio, USA.

Andrew Jajack (A)

Novel Devices Laboratory, University of Cincinnati, Cincinnati, Ohio, USA. jajackaj@mail.uc.edu.

Benjamin Feldman (B)

Abbott Diabetes Care, Alameda, CA, USA.

Steve W Granger (SW)

Salimetrics LLC, Carlsbad, California, USA.

Supriya Gaitonde (S)

Salimetrics LLC, Carlsbad, California, USA.

Gavi Begtrup (G)

Eccrine Systems Inc, Cincinnati, Ohio, USA.

Benjamin A Katchman (BA)

Eccrine Systems Inc, Cincinnati, Ohio, USA.

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