Changes in Interhemispheric Motor Connectivity Across the Lifespan: A Combined TMS and DTI Study.
DTI
ISP
TMS
age
interhemispheric inhibition
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
09
2018
accepted:
14
01
2019
entrez:
27
2
2019
pubmed:
26
2
2019
medline:
26
2
2019
Statut:
epublish
Résumé
Age-related decline in interhemispheric connectivity between motor areas has been reported with both transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) measurements. However, not all studies were able to confirm these findings, and previous studies did not apply structural (DTI) and functional (TMS) measurements within each individual appropriately. Here, we investigated age dependency of the ipsilateral silent period (ISP) and integrity of fibers in the corpus callosum as operationalized by fractional anisotrophy (FA), using TMS and DTI, respectively, in 20 participants between 19 and 72 years of age. We found age-dependent increase for ISP, and decrease of FA, both indicating a decrease in interhemispheric inhibition, with a negative association between FA and ISP for the dominant hemisphere (
Identifiants
pubmed: 30804775
doi: 10.3389/fnagi.2019.00012
pmc: PMC6371065
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12Références
J Physiol. 1992;453:525-46
pubmed: 1464843
Neuroimage. 2006 Jul 15;31(4):1453-74
pubmed: 16571375
Neurosci Biobehav Rev. 2014 Jun;43:100-17
pubmed: 24726575
Clin Neurophysiol. 2013 Feb;124(2):346-53
pubmed: 22883478
Neural Plast. 2012;2012:627816
pubmed: 23304559
J Neurophysiol. 2003 Mar;89(3):1256-64
pubmed: 12611955
Clin Neurophysiol. 2015 Jun;126(6):1071-1107
pubmed: 25797650
Brain Connect. 2011;1(4):279-93
pubmed: 22432418
Exp Brain Res. 2004 Sep;158(2):133-40
pubmed: 15118793
Brain Struct Funct. 2019 May;224(4):1447-1455
pubmed: 30778685
Neurobiol Aging. 2012 Oct;33(10):2521-6
pubmed: 22177217
Front Hum Neurosci. 2016 Mar 09;10:101
pubmed: 27014032
Behav Brain Res. 2015 Feb 1;278:393-403
pubmed: 25194587
Brain Res Brain Res Rev. 2005 Nov;49(3):641-62
pubmed: 15904971
Behav Brain Res. 2012 Jan 1;226(1):211-7
pubmed: 21944939
J Physiol. 2009 Nov 15;587(Pt 22):5393-410
pubmed: 19770195
Neurosci Lett. 2008 Nov 21;445(3):209-13
pubmed: 18793696
PLoS One. 2015 Sep 02;10(8):e0135247
pubmed: 26332788
Magn Reson Med. 2003 Nov;50(5):1077-88
pubmed: 14587019
BMC Neurosci. 2013 Jun 25;14:62
pubmed: 23800346
Front Aging Neurosci. 2017 Dec 11;9:412
pubmed: 29321739
Hum Brain Mapp. 2015 Oct;36(10):3777-92
pubmed: 26173024
Electroencephalogr Clin Neurophysiol. 1998 Jun;109(3):230-7
pubmed: 9741789
Neuropsychol Rev. 2014 Sep;24(3):271-89
pubmed: 25146995
Muscle Nerve. 2006 Oct;34(4):431-6
pubmed: 16810689
Clin Neurophysiol. 1999 Apr;110(4):748-56
pubmed: 10378748
J Neurophysiol. 2013 Feb;109(4):1091-6
pubmed: 23221418
Neurosci Lett. 2004 Sep 2;367(2):189-93
pubmed: 15331150
J Neurosci. 2007 Nov 7;27(45):12132-8
pubmed: 17989279
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Front Aging Neurosci. 2014 Aug 11;6:209
pubmed: 25157232
Neurobiol Aging. 2010 Mar;31(3):464-81
pubmed: 18495300
Clin Neurophysiol. 2008 Apr;119(4):744-62
pubmed: 18187362
AJNR Am J Neuroradiol. 2011 Dec;32(11):2103-9
pubmed: 21998104
Neurobiol Aging. 2012 Jan;33(1):21-34
pubmed: 20363050