Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss.
Aging
Bone
Bone homeostasis
Insulin receptor
S100a4
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
04
10
2018
revised:
28
01
2019
accepted:
01
02
2019
entrez:
27
2
2019
pubmed:
26
2
2019
medline:
26
2
2019
Statut:
epublish
Résumé
Type I and Type II Diabetes dramatically impair skeletal health. Altered Insulin Receptor (IR) signaling is a common feature of both diseases, and insulin has potent bone anabolic functions. Several previous studies have demonstrated that loss of IR in bone cells results in disrupted bone homeostasis during early post-natal growth. Here we have deleted IR in S100a4-lineage cells (IRcKO
Identifiants
pubmed: 30805422
doi: 10.1016/j.bonr.2019.100197
pii: S2352-1872(19)30003-8
pii: 100197
pmc: PMC6374520
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100197Subventions
Organisme : NIAMS NIH HHS
ID : K01 AR068386
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069655
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073169
Pays : United States
Commentaires et corrections
Type : ErratumIn
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