Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.
Alpha-synuclein protein
Lewy bodies
Lewy neurites
Memory B cell
Monoclonal antibody
Parkinson’s disease
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
01
01
2019
accepted:
08
02
2019
revised:
06
02
2019
pubmed:
26
2
2019
medline:
10
7
2020
entrez:
27
2
2019
Statut:
ppublish
Résumé
Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson's disease (PD). It is hypothesized that α-synuclein pathology spreads by a "prion-like" mechanism (i.e., by seeded aggregation or templated misfolding). Therefore, various extracellular α-synuclein conformers and/or posttranslational modifications may serve as biomarkers of disease or potential targets for novel interventions. To explore whether the antibody repertoires of PD patients contain anti-α-synuclein antibodies that can potentially be used as markers or immunotherapy, we interrogated peripheral IgG
Identifiants
pubmed: 30805666
doi: 10.1007/s00401-019-01974-5
pii: 10.1007/s00401-019-01974-5
pmc: PMC6482120
doi:
Substances chimiques
Antibodies
0
SNCA protein, human
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
825-836Références
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