A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression.
CTLA-4 Antigen
/ metabolism
Drug Evaluation, Preclinical
/ methods
Forkhead Transcription Factors
/ genetics
Gene Expression Regulation
/ drug effects
Gene Knockdown Techniques
Glycogen Synthase Kinase 3
/ metabolism
Histone-Lysine N-Methyltransferase
/ metabolism
Humans
Phenotype
Protein Domains
/ drug effects
RNA, Small Interfering
/ metabolism
Small Molecule Libraries
/ chemistry
Structure-Activity Relationship
T-Lymphocytes, Regulatory
/ metabolism
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
15 03 2019
15 03 2019
Historique:
pubmed:
27
2
2019
medline:
18
12
2019
entrez:
27
2
2019
Statut:
ppublish
Résumé
Regulatory T (Treg) cells, expressing the transcription factor forkhead box p3 (FOXP3), are the key cells regulating peripheral autoreactive T lymphocytes by suppressing effector T cells. FOXP3
Identifiants
pubmed: 30807094
doi: 10.1021/acschembio.9b00075
doi:
Substances chimiques
CTLA-4 Antigen
0
CTLA4 protein, human
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
RNA, Small Interfering
0
Small Molecule Libraries
0
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Glycogen Synthase Kinase 3
EC 2.7.11.26
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM