Cumambrin A prevents OVX-induced osteoporosis

Animals Bone Resorption / drug therapy Cell Differentiation Mice Mice, Inbred C57BL NF-kappa B / genetics Osteoclasts / cytology Osteogenesis / drug effects Osteoporosis / etiology Ovariectomy / adverse effects RANK Ligand / genetics RAW 264.7 Cells Sesquiterpenes / pharmacology Signal Transduction
ERK NF-κB NFATc1 osteolysis

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
06 2019
Historique:
pubmed: 27 2 2019
medline: 22 5 2020
entrez: 27 2 2019
Statut: ppublish

Résumé

Being the principal cells responsible for bone resorption and pathologic bone loss, osteoclasts have become the main target for antiresorptive treatment. Cumambrin A is a natural compound isolated from

Identifiants

DOI: 10.1096/fj.201800883RRR PMID: 30807230
pubmed: 30807230
doi: 10.1096/fj.201800883RRR
doi:

Substances chimiques

NF-kappa B 0
RANK Ligand 0
Sesquiterpenes 0
Tnfsf11 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6726-6735

Auteurs

Lin Zhou (L)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Department of Endocrinology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Qian Liu (Q)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.

Guoju Hong (G)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Orthopedic Department, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Fangming Song (F)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.

Jinmin Zhao (J)

Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.

Jinbo Yuan (J)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.

Jun Xu (J)

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

Ren Xiang Tan (RX)

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China.

Jennifer Tickner (J)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.

Qiong Gu (Q)

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

Jiake Xu (J)

School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Ovariectomie › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de RANK › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Cumambrin A prevents OVX-induced osteoporosis
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Cumambrin A prevents OVX-induced osteoporosis