The emerging role of epigenetics in human autoimmune disorders.
Autoimmune diseases
Epigenetic pathways
Epigenetics
Gene expression
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
received:
23
12
2018
accepted:
12
02
2019
entrez:
28
2
2019
pubmed:
28
2
2019
medline:
22
1
2020
Statut:
epublish
Résumé
Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of autoimmune disorders. Epigenetic changes, such as DNA methylation, histone modifications, and noncoding RNAs, are involved in the pathogenesis of autoimmune diseases mainly by regulating gene expression. This paper reviews the importance of epigenetic alterations during the development of the most prevalent human autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjogren's syndrome (SS), autoimmune thyroid diseases (AITD), and type 1 diabetes (T1D), aiming to provide new insights in the pathogenesis of autoimmune diseases and the possibility to develop novel therapeutic approaches targeting the epigenome.
Identifiants
pubmed: 30808407
doi: 10.1186/s13148-019-0632-2
pii: 10.1186/s13148-019-0632-2
pmc: PMC6390373
doi:
Substances chimiques
RNA, Untranslated
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
34Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114306
Pays : United States
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