Factors influencing the incidence of Hirschsprung associated enterocolitis (HAEC).


Journal

Journal of pediatric surgery
ISSN: 1531-5037
Titre abrégé: J Pediatr Surg
Pays: United States
ID NLM: 0052631

Informations de publication

Date de publication:
May 2019
Historique:
received: 16 01 2019
accepted: 27 01 2019
pubmed: 28 2 2019
medline: 31 7 2019
entrez: 28 2 2019
Statut: ppublish

Résumé

This study aims to characterize risk factors for Hirschsprung-associated enterocolitis (HAEC). We hypothesize that earlier pull-through surgery is associated with lower risks of developing postoperative HAEC. A comparative study of 171 Hirschsprung patients treated from 1990 to 2017 was performed. Patients without HAEC were compared to patients with preoperative and/or postoperative HAEC. Results are presented as median [IQR] or frequency (%). Pearson's χ Risk of developing preoperative HAEC was significantly associated with congenital malformations (OR 2.63 [1.11, 6.24]; p = 0.02). Birth weight was lower in patients with preoperative HAEC (OR 0.48 [95% CI 0.25, 0.93]; p = 0.03). On regression analysis, intestinal obstruction after surgery was significantly associated with postoperative HAEC (OR 8.2 [3.18, 21.13]; p < 0.0001). Patients with earlier pull-through surgery did not have a lower risk of developing postoperative HAEC. Timing of surgery does not seem to be associated with a higher risk of developing pre- and postoperative HAEC. Predisposing factors for preoperative HAEC included associated malformations and lower birth weight, whereas intestinal obstruction was found to be associated with postoperative HAEC. Treatment study. Level III.

Identifiants

pubmed: 30808539
pii: S0022-3468(19)30063-6
doi: 10.1016/j.jpedsurg.2019.01.026
pii:
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Pagination

959-963

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Annie Le-Nguyen (A)

Division of General Surgery, University of Montreal, Montreal, Canada.

Franziska Righini-Grunder (F)

Division of Pediatric Gastroenterology, Hepatology and Nutrition, CHU Ste-Justine, Montreal, Canada; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's hospital, Lucerne, Switzerland.

Nelson Piché (N)

Division of Pediatric Surgery, CHU Ste-Justine, University of Montreal, Montreal, Canada.

Christophe Faure (C)

Division of Pediatric Gastroenterology, Hepatology and Nutrition, CHU Ste-Justine, Montreal, Canada.

Ann Aspirot (A)

Division of Pediatric Surgery, CHU Ste-Justine, University of Montreal, Montreal, Canada. Electronic address: ann.aspirot@videotron.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH