Factors influencing the incidence of Hirschsprung associated enterocolitis (HAEC).
Birth Weight
Congenital Abnormalities
/ epidemiology
Enterocolitis
/ epidemiology
Female
Hirschsprung Disease
/ complications
Humans
Incidence
Infant
Infant, Newborn
Intestinal Obstruction
/ epidemiology
Laparoscopy
Male
Postoperative Period
Preoperative Period
Risk Factors
Time Factors
Transanal Endoscopic Surgery
Complications
HSCR
Hirschsprung disease
Hirschsprung-associated enterocolitis
Pull-through surgery
Risk factors
Journal
Journal of pediatric surgery
ISSN: 1531-5037
Titre abrégé: J Pediatr Surg
Pays: United States
ID NLM: 0052631
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
16
01
2019
accepted:
27
01
2019
pubmed:
28
2
2019
medline:
31
7
2019
entrez:
28
2
2019
Statut:
ppublish
Résumé
This study aims to characterize risk factors for Hirschsprung-associated enterocolitis (HAEC). We hypothesize that earlier pull-through surgery is associated with lower risks of developing postoperative HAEC. A comparative study of 171 Hirschsprung patients treated from 1990 to 2017 was performed. Patients without HAEC were compared to patients with preoperative and/or postoperative HAEC. Results are presented as median [IQR] or frequency (%). Pearson's χ Risk of developing preoperative HAEC was significantly associated with congenital malformations (OR 2.63 [1.11, 6.24]; p = 0.02). Birth weight was lower in patients with preoperative HAEC (OR 0.48 [95% CI 0.25, 0.93]; p = 0.03). On regression analysis, intestinal obstruction after surgery was significantly associated with postoperative HAEC (OR 8.2 [3.18, 21.13]; p < 0.0001). Patients with earlier pull-through surgery did not have a lower risk of developing postoperative HAEC. Timing of surgery does not seem to be associated with a higher risk of developing pre- and postoperative HAEC. Predisposing factors for preoperative HAEC included associated malformations and lower birth weight, whereas intestinal obstruction was found to be associated with postoperative HAEC. Treatment study. Level III.
Identifiants
pubmed: 30808539
pii: S0022-3468(19)30063-6
doi: 10.1016/j.jpedsurg.2019.01.026
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Pagination
959-963Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.