Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
02 05 2019
02 05 2019
Historique:
received:
03
10
2018
accepted:
19
02
2019
pubmed:
28
2
2019
medline:
18
12
2019
entrez:
28
2
2019
Statut:
ppublish
Résumé
The hematopoietic system produces new blood cells throughout life. Mature blood cells all derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew to maintain the stem cell pool and to insure the continuous replenishment of blood cells. Mitochondria have recently emerged as critical not only for HSC differentiation and commitment but also for HSC homeostasis. Mitochondria are dynamic organelles that orchestrate a number of fundamental metabolic and signaling processes, producing most of the cellular energy via oxidative phosphorylation. HSCs have a relatively high amount of mitochondria that are mostly inactive. Here, we review recent advances in our understanding of the role of mitochondria in HSC homeostasis and discuss, among other topics, how mitochondrial dynamism and quality control might be implicated in HSC fate, self-renewal, and regenerative potential.
Identifiants
pubmed: 30808633
pii: S0006-4971(20)42588-1
doi: 10.1182/blood-2018-10-808873
pmc: PMC6497515
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1943-1952Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM112792
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK077174
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102890
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205975
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136255
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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