Genome-wide association study suggests impact of chromosome 10 rs139401390 on kidney function in patients with coronary artery disease.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
26 02 2019
Historique:
received: 13 08 2018
accepted: 15 01 2019
entrez: 28 2 2019
pubmed: 28 2 2019
medline: 22 9 2020
Statut: epublish

Résumé

Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30-75 ml/min/1.73 m

Identifiants

pubmed: 30809046
doi: 10.1038/s41598-019-39055-y
pii: 10.1038/s41598-019-39055-y
pmc: PMC6391429
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2750

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Auteurs

Boris Schmitz (B)

Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany.

Marcus E Kleber (ME)

Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany.

Malte Lenders (M)

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.

Graciela E Delgado (GE)

Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.

Christiane Engelbertz (C)

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.
Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Jie Huang (J)

Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

Hermann Pavenstädt (H)

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.

Günter Breithardt (G)

Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Stefan-Martin Brand (SM)

Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany.

Winfried März (W)

Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.

Eva Brand (E)

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany. Eva.Brand@ukmuenster.de.

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