Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility.
Alzheimer's diseases
brain
focused ultrasounds
neurodegenerative diseases
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
11
2018
accepted:
01
12
2018
entrez:
28
2
2019
pubmed:
28
2
2019
medline:
3
3
2020
Statut:
epublish
Résumé
The use of focused ultrasound (FUS) as a tool for blood-brain barrier (BBB) permeabilization is opening new ways for the treatment of several pathologies, in particular brain tumors and neurodegenerative diseases. However, even if there are promising results in these fields, the efficacy and safety of this technique is unknown in long-term follow-up. The study of Blackmore et al. [Theranostics 2018; 8(22):6233-6247. doi:10.7150/thno.27941] evaluated the long-term effects of FUS on brain parenchyma in aged mice with Alzheimer's disease. This is the first study which applied a multimodal analysis to demonstrate the safety of FUS in aged brain in view of a potential introduction of this technique in common clinical practice in the future.
Identifiants
pubmed: 30809291
doi: 10.7150/thno.31765
pii: thnov09p0537
pmc: PMC6376189
doi:
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
537-539Commentaires et corrections
Type : CommentOn
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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