The significance of batch and patch test method in establishing contact allergy to fragrance mix I-EDEN Fragrance Study Group.
Evernia prunastri
allergic contact dermatitis
chloratranol/atranol
delayed hypersensitivity
general population
oak moss
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
29
11
2018
revised:
20
02
2019
accepted:
23
02
2019
pubmed:
28
2
2019
medline:
7
1
2020
entrez:
28
2
2019
Statut:
ppublish
Résumé
A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy to FM I than testing with the Finn Chamber technique. To investigate the possible significance of batch and patch test method in establishing contact allergy to FM I. Three thousand one hundred and nineteen individuals representing a sample of the general population were patch tested with two batches of FM I with two patch test techniques at six dermatology clinics in five European countries. The TRUE Test technique and the Finn Chamber technique with pet. preparations were used. McNemar's test was used for statistical calculations. The contact allergy prevalences varied between 0.7% and 2.6%. The patch tests with the mixes containing Evernia prunastri (oak moss) with a high content of chloratranol/atranol resulted in substantially more positive reactions than the corresponding tests with the mixes containing oak moss with a low content of chloratranol/atranol. The Finn Chamber technique detected significantly more contact allergic reactions than the TRUE Test technique (P < 0.001). The Finn Chamber technique detects more contact allergy to FM I than the TRUE Test technique.
Sections du résumé
BACKGROUND
BACKGROUND
A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy to FM I than testing with the Finn Chamber technique.
OBJECTIVE
OBJECTIVE
To investigate the possible significance of batch and patch test method in establishing contact allergy to FM I.
METHODS
METHODS
Three thousand one hundred and nineteen individuals representing a sample of the general population were patch tested with two batches of FM I with two patch test techniques at six dermatology clinics in five European countries. The TRUE Test technique and the Finn Chamber technique with pet. preparations were used. McNemar's test was used for statistical calculations.
RESULTS
RESULTS
The contact allergy prevalences varied between 0.7% and 2.6%. The patch tests with the mixes containing Evernia prunastri (oak moss) with a high content of chloratranol/atranol resulted in substantially more positive reactions than the corresponding tests with the mixes containing oak moss with a low content of chloratranol/atranol. The Finn Chamber technique detected significantly more contact allergic reactions than the TRUE Test technique (P < 0.001).
CONCLUSION
CONCLUSIONS
The Finn Chamber technique detects more contact allergy to FM I than the TRUE Test technique.
Substances chimiques
Allergens
0
Types de publication
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-109Subventions
Organisme : Research Institute for Fragrance Materials
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.