Selection of a fully human single domain antibody specific to Helicobacter pylori urease.
Antibody targeting
Flap region
Helicobacter pylori
Phage display
UreB
Urease enzyme
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
07
09
2018
accepted:
30
01
2019
revised:
29
01
2019
pubmed:
28
2
2019
medline:
26
7
2019
entrez:
28
2
2019
Statut:
ppublish
Résumé
Helicobacter pylori bacteria are involved in gastroduodenal disorders, including gastric adenocarcinoma. Since the current therapies encounter with some significant shortcomings, much attention has been paid to the development of new alternative diagnostic and treatment modalities such as immunomedicines to target H. pylori. Having used phage display technology, we isolated fully humane small antibody (Ab) fragment (V
Identifiants
pubmed: 30810777
doi: 10.1007/s00253-019-09674-6
pii: 10.1007/s00253-019-09674-6
doi:
Substances chimiques
Antibodies, Bacterial
0
Bacterial Proteins
0
Enzyme Inhibitors
0
Peptide Library
0
Single-Domain Antibodies
0
Urease
EC 3.5.1.5
Types de publication
Journal Article
Langues
eng
Pagination
3407-3420Subventions
Organisme : Tabriz University of Medical Sciences
ID : RCPN-93006