Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner.
Animals
Cells, Cultured
Female
Immunity, Humoral
Inflammation
/ immunology
Influenza Vaccines
/ immunology
Interferon Type I
/ physiology
Interferon-gamma
/ metabolism
Interleukin-6
/ biosynthesis
Killer Cells, Natural
/ immunology
Lymph Nodes
/ immunology
Macrophages
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
IFNγ
IL-6
dendritic cell
influenza vaccine
natural killer cell
type I IFN
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
received:
06
02
2018
revised:
11
12
2018
accepted:
28
01
2019
entrez:
28
2
2019
pubmed:
28
2
2019
medline:
17
4
2020
Statut:
ppublish
Résumé
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFNγ, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.
Identifiants
pubmed: 30811982
pii: S2211-1247(19)30141-X
doi: 10.1016/j.celrep.2019.01.104
pii:
doi:
Substances chimiques
Influenza Vaccines
0
Interferon Type I
0
Interleukin-6
0
interleukin-6, mouse
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2307-2315.e5Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.