An Electrostatic Energy Barrier for SNARE-Dependent Spontaneous and Evoked Synaptic Transmission.

Animals Cells, Cultured Excitatory Postsynaptic Potentials Female Male Membrane Fusion Mice Mice, Knockout Models, Neurological SNARE Proteins / chemistry Static Electricity Synaptic Transmission Synaptic Vesicles / metabolism Synaptotagmin I / physiology
SNAP-25 SNARE-complex autaptic neuron energy barrier glutamatergic synapse mathematical modeling membrane fusion spontaneous release synaptic transmission synaptotagmin-1

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 02 2019
Historique:
received: 05 06 2018
revised: 05 11 2018
accepted: 28 01 2019
entrez: 28 2 2019
pubmed: 28 2 2019
medline: 17 4 2020
Statut: ppublish

Résumé

Information transfer across CNS synapses depends on the very low basal vesicle fusion rate and the ability to rapidly upregulate that rate upon Ca

Identifiants

DOI: 10.1016/j.celrep.2019.01.103 PMID: 30811985
pubmed: 30811985
pii: S2211-1247(19)30140-8
doi: 10.1016/j.celrep.2019.01.103
pii:
doi:

Substances chimiques

SNARE Proteins 0
Synaptotagmin I 0
Syt1 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2340-2352.e5

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Marvin Ruiter (M)

Department of Neuroscience, Faculty of Health and Medical Sciences, 2200 Copenhagen N, University of Copenhagen, Copenhagen, Denmark.

Anna Kádková (A)

Department of Neuroscience, Faculty of Health and Medical Sciences, 2200 Copenhagen N, University of Copenhagen, Copenhagen, Denmark.

Andrea Scheutzow (A)

Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.

Jörg Malsam (J)

Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.

Thomas H Söllner (TH)

Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.

Jakob B Sørensen (JB)

Department of Neuroscience, Faculty of Health and Medical Sciences, 2200 Copenhagen N, University of Copenhagen, Copenhagen, Denmark. Electronic address: jakobbs@sund.ku.dk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Cellules › Cellules cultivées › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Fusion membranaire › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles neurologiques › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électricité › Électricité statique › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › An Electrostatic Energy Barrier for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Synaptotagmines › Synaptotagmine I › An Electrostatic Energy Barrier for...