Influence of nanoporous titanium niobium alloy surfaces produced via hydrogen peroxide oxidative etching on the osteogenic differentiation of human mesenchymal stromal cells.
Bone replacement
Cellular response
Nanopores
Titanium niobium alloy
Young's modulus
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
14
05
2018
revised:
20
12
2018
accepted:
07
01
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
14
6
2019
Statut:
ppublish
Résumé
Titanium niobium alloys exhibit a lower stiffness compared to Ti6Al4V, the 'gold standard' for load-bearing bone implants. Thus, the critical mismatch in stiffness between the implant and adjacent bone tissue could be addressed with TiNb alloys and thereby reduce stress shielding, which can result in bone resorption and subsequent implant loosening; however, the cellular response on the specific material is crucial for sufficient osseointegration. We therefore hypothesize that the response of human mesenchymal stromal cells (hMSC) and osteoblast-like cells on Ti45Nb surfaces can be improved by a novel nanoporous surface structure. For this purpose, an etching technique using hydrogen peroxide electrolyte solution was applied to Ti45Nb. The treated surfaces were characterized using SEM, LSM, AFM, nanoindentation, and contact angle measurements. Cell culture experiments using hMCS and MG-63 were conducted. The H
Identifiants
pubmed: 30813067
pii: S0928-4931(18)31364-X
doi: 10.1016/j.msec.2019.01.023
pii:
doi:
Substances chimiques
Alloys
0
titanium-niobium alloy
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
635-648Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.