Immune System Modulation and Viral Persistence in Bats: Understanding Viral Spillover.
Immune response
bats
flight
immune tolerance
spillover
viral persistence
viruses
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
23 02 2019
23 02 2019
Historique:
received:
23
01
2019
revised:
17
02
2019
accepted:
20
02
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
21
8
2019
Statut:
epublish
Résumé
Bats harbor a myriad of viruses and some of these viruses may have spilled over to other species including humans. Spillover events are rare and several factors must align to create the "perfect storm" that would ultimately lead to a spillover. One of these factors is the increased shedding of virus by bats. Several studies have indicated that bats have unique defense mechanisms that allow them to be persistently or latently infected with viruses. Factors leading to an increase in the viral load of persistently infected bats would facilitate shedding of virus. This article reviews the unique nature of bat immune defenses that regulate virus replication and the various molecular mechanisms that play a role in altering the balanced bat⁻virus relationship.
Identifiants
pubmed: 30813403
pii: v11020192
doi: 10.3390/v11020192
pmc: PMC6410205
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
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