Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in

Acoustics Animals Astrocytes / metabolism Disease Susceptibility Down-Regulation Epilepsy, Reflex / drug therapy Glial Fibrillary Acidic Protein / metabolism Intercellular Signaling Peptides and Proteins Male Mutation / genetics Potassium Channels, Inwardly Rectifying / genetics Proteins / genetics Rats, Inbred F344 Valproic Acid / pharmacology
ADLTE Kir4.1 channels Lgi1 antiepileptics astrocytes epilepsy valproic acid

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Feb 2019
Historique:
received: 10 01 2019
revised: 14 02 2019
accepted: 21 02 2019
entrez: 1 3 2019
pubmed: 1 3 2019
medline: 19 6 2019
Statut: epublish

Résumé

The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional changes in

Identifiants

DOI: 10.3390/ijms20051013 PMID: 30813600 PMC: PMC6429235
pubmed: 30813600
pii: ijms20051013
doi: 10.3390/ijms20051013
pmc: PMC6429235
pii:
doi:

Substances chimiques

Glial Fibrillary Acidic Protein 0
Intercellular Signaling Peptides and Proteins 0
Kcnj10 (channel) 0
Lgi1 protein, rat 0
Potassium Channels, Inwardly Rectifying 0
Proteins 0
Valproic Acid 614OI1Z5WI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Japan Agency for Medical Research and Development
ID : 17ek0109120h0003
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 17K08324
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 15H04892
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 16K21501
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 15H05874
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 15H04270

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Auteurs

Masato Kinboshi (M)

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. kinboshi@kuhp.kyoto-u.ac.jp.
Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan. kinboshi@kuhp.kyoto-u.ac.jp.
Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. kinboshi@kuhp.kyoto-u.ac.jp.
ORCID: 0000-0002-5556-8336

Saki Shimizu (S)

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. s.shimizu@gly.oups.ac.jp.

Tomoji Mashimo (T)

Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. mashimo@iexas.med.osaka-u.ac.jp.

Tadao Serikawa (T)

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. serikawa@anim.med.kyoto-u.ac.jp.

Hidefumi Ito (H)

Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan. itohid@kuhp.kyoto-u.ac.jp.

Akio Ikeda (A)

Department of Epilepsy, Movement Disorders and Physiology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. akio@kuhp.kyoto-u.ac.jp.

Ryosuke Takahashi (R)

Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. ryosuket@kuhp.kyoto-u.ac.jp.

Yukihiro Ohno (Y)

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. yohno@gly.oups.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Acoustique › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Eucaryotes › Animaux › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Épilepsie réflexe › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Protéine gliofibrillaire acide › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › Down-Regulation of Astrocytic Kir4.1 Channels...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Valérates › Acides pentanoïques › Acide valproïque › Down-Regulation of Astrocytic Kir4.1 Channels...