Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy.
Atg16l1
Intestinal organoids
Paneth cells
Quantitative proteomics
Selective autophagy
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
18 03 2019
18 03 2019
Historique:
received:
05
09
2018
accepted:
01
02
2019
pubmed:
1
3
2019
medline:
14
8
2019
entrez:
1
3
2019
Statut:
epublish
Résumé
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive pathologies such as Crohn's disease or infections. Similar alterations are observed in individuals with impaired autophagy, a process that recycles cellular components. The direct effect of autophagy impairment on Paneth cells has not been analysed. To investigate this, we generated a mouse model lacking
Identifiants
pubmed: 30814064
pii: dmm.037069
doi: 10.1242/dmm.037069
pmc: PMC6451430
pii:
doi:
Substances chimiques
Atg16l1 protein, mouse
0
Autophagy-Related Proteins
0
Carrier Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/00044409
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011216/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100,974/C/13/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/CSP17270/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P016774/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004529/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10353
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/T/000PR9817
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J01754X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10355
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10356
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/CCG1720/1
Pays : United Kingdom
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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