Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.
Journal
NPJ schizophrenia
ISSN: 2334-265X
Titre abrégé: NPJ Schizophr
Pays: United States
ID NLM: 101657919
Informations de publication
Date de publication:
27 Feb 2019
27 Feb 2019
Historique:
received:
05
09
2018
accepted:
07
02
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
1
3
2019
Statut:
epublish
Résumé
The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.
Identifiants
pubmed: 30814520
doi: 10.1038/s41537-019-0072-1
pii: 10.1038/s41537-019-0072-1
pmc: PMC6393510
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 26461718
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 17H04249
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 15K19727
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18K15483
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 16K19765
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