A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.

Aging Animals Cartilage / cytology Cell Self Renewal Chondrocytes / cytology Clone Cells / cytology Female Growth Plate / cytology Male Mechanistic Target of Rapamycin Complex 1 / metabolism Mice Stem Cell Niche / physiology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
03 2019
Historique:
received: 29 09 2017
accepted: 01 02 2019
pubmed: 1 3 2019
medline: 17 9 2019
entrez: 1 3 2019
Statut: ppublish

Résumé

Longitudinal bone growth in children is sustained by growth plates, narrow discs of cartilage that provide a continuous supply of chondrocytes for endochondral ossification

Identifiants

DOI: 10.1038/s41586-019-0989-6 PMID: 30814736
pubmed: 30814736
doi: 10.1038/s41586-019-0989-6
pii: 10.1038/s41586-019-0989-6
doi:

Substances chimiques

Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

234-238

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Auteurs

Phillip T Newton (PT)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. phillip.newton@ki.se.
Department of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden. phillip.newton@ki.se.

Lei Li (L)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Baoyi Zhou (B)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Christoph Schweingruber (C)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Maria Hovorakova (M)

Department of Developmental Biology, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.

Meng Xie (M)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Xiaoyan Sun (X)

Department of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

Lakshmi Sandhow (L)

Center for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden.

Artem V Artemov (AV)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Evgeny Ivashkin (E)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Simon Suter (S)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Vyacheslav Dyachuk (V)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russian Federation.

Maha El Shahawy (M)

Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Amel Gritli-Linde (A)

Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Thibault Bouderlique (T)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Julian Petersen (J)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, Vienna, Austria.

Annelie Mollbrink (A)

Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.

Joakim Lundeberg (J)

Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.

Grigori Enikolopov (G)

Center for Developmental Genetics and Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA.

Hong Qian (H)

Center for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden.

Kaj Fried (K)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Maria Kasper (M)

Department of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

Eva Hedlund (E)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Igor Adameyko (I)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, Vienna, Austria.

Lars Sävendahl (L)

Department of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden.

Andrei S Chagin (AS)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. andrei.chagin@ki.se.
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation. andrei.chagin@ki.se.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Eucaryotes › Animaux › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Auto-renouvellement cellulaire › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Appareil locomoteur › Squelette › Épiphyses (os) › Lame épiphysaire › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A radical switch in clonality reveals a stem...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › A radical switch in clonality reveals a stem...