MLC901 during sleep deprivation rescues fear memory disruption in rats.
Animals
Apoptosis Regulatory Proteins
/ metabolism
Conditioning, Psychological
Disease Models, Animal
Dose-Response Relationship, Drug
Drugs, Chinese Herbal
/ pharmacology
Fear
/ drug effects
Hippocampus
/ drug effects
Male
Memory Disorders
/ metabolism
Rats, Wistar
Retention, Psychology
/ drug effects
Sleep Deprivation
/ drug therapy
Fear memory conditioning
MLC901
Rat
Sleep deprivation
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
04
08
2018
accepted:
28
12
2018
pubmed:
2
3
2019
medline:
21
5
2020
entrez:
2
3
2019
Statut:
ppublish
Résumé
Several lines of evidence suggest that sleep deprivation disrupts cognitive and emotional abilities and changes the expression of distinctive categories of genes in the brain. In the present study, saline- or MLC901 (a traditional Chinese medicine)-treated male Wistar rats were first submitted to a modified water box (for 24-h sleep deprivation) and then trained in contextual and tone fear conditioning tasks with the purpose to evaluate the effect of MLC901 during sleep deprivation on fear memory retention. Hippocampal mRNA measurement was performed by reverse transcription-polymerase chain reaction (RT-PCR). We found that the exposure of rats to 24 h of sleep deprivation impaired contextual and tone fear memory retention, while administration of MLC901 (0.2, 0.4, and 0.8 mg/kg, once/12 h; i.p.) during sleep deprivation abolished memory deficits. Meanwhile, different doses of MLC901 alone had no effect on performance in both tasks. We observed that MLC901 increased the expression levels of pro-apoptotic BAD, anti-apoptotic Bcl-xL, and Tfam as an index of mitochondrial biogenesis compared to sleep-deprived rats, while MLC901 during sleep deprivation increased BAX, BAD, and Bcl-xL compared to the control group. Sleep deprivation decreased BAX and Tfam, by itself. MLC901 only decreased BAX and Tfam and increased BAD level compared to the non-sleep-deprived control group. It is suggested that MLC901 might be a therapeutic option for memory impairment during sleep deprivation.
Identifiants
pubmed: 30820610
doi: 10.1007/s00210-018-01612-z
pii: 10.1007/s00210-018-01612-z
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Drugs, Chinese Herbal
0
Neuroaid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
813-821Références
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