Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion.

Animals CD4-Positive T-Lymphocytes / immunology Graft Rejection / etiology Graft Survival / immunology Heterografts Immune Tolerance / immunology Kidney Transplantation / adverse effects Lymphocyte Depletion / adverse effects Macaca mulatta Swine
animal models: nonhuman primate basic (laboratory) research/science costimulation immunosuppressant - fusion proteins and monoclonal antibodies: costimulation molecule specific immunosuppression/immune modulation kidney transplantation/nephrology translational research/science xenoantibody xenoantigen xenotransplantation

Journal

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638

Informations de publication

Date de publication:
08 2019
Historique:
received: 12 03 2018
revised: 22 01 2019
accepted: 04 02 2019
pubmed: 2 3 2019
medline: 1 9 2020
entrez: 2 3 2019
Statut: ppublish

Résumé

The shortage of available organs remains the greatest barrier to expanding access to transplant. Despite advances in genetic editing and immunosuppression, survival in experimental models of kidney xenotransplant has generally been limited to <100 days. We found that pretransplant selection of recipients with low titers of anti-pig antibodies significantly improved survival in a pig-to-rhesus macaque kidney transplant model (6 days vs median survival time 235 days). Immunosuppression included transient pan-T cell depletion and an anti-CD154-based maintenance regimen. Selective depletion of CD4

Identifiants

DOI: 10.1111/ajt.15329 PMID: 30821922 PMC: PMC6658347
pubmed: 30821922
doi: 10.1111/ajt.15329
pmc: PMC6658347
mid: NIHMS1014924
pii: S1600-6135(22)09184-5
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2174-2185

Subventions

Organisme : NIH HHS
ID : U42 OD011140
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008169
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : Carlos and Marguerite Mason Trust
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI126322
Pays : United States

Informations de copyright

© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.

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Auteurs

Steven C Kim (SC)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

David V Mathews (DV)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

Cynthia P Breeden (CP)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

Laura B Higginbotham (LB)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

Joseph Ladowski (J)

National Swine Resource and Research Center, University of Missouri, Columbia, Missouri.

Gregory Martens (G)

National Swine Resource and Research Center, University of Missouri, Columbia, Missouri.

Allison Stephenson (A)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

Alton B Farris (AB)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.

Elizabeth A Strobert (EA)

Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia.

Joe Jenkins (J)

Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia.

Eric M Walters (EM)

National Swine Resource and Research Center, University of Missouri, Columbia, Missouri.

Christian P Larsen (CP)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.
Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia.

Matthew Tector (M)

Comprehensive Transplant Institute, University of Alabama Birmingham School of Medicine, Birmingham, Alabama.

Alfred J Tector (AJ)

Comprehensive Transplant Institute, University of Alabama Birmingham School of Medicine, Birmingham, Alabama.

Andrew B Adams (AB)

Emory Transplant Center, Department of Surgery, School of Medicine, Emory University, Atlanta, Georgia.
Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Déplétion lymphocytaire › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Long-term survival of pig-to-rhesus macaque...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Long-term survival of pig-to-rhesus macaque...