Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives.
Combination therapy
cobinamide
dimethyl trisulfide
intramuscular antidote injection
subcutaneous cyanide exposure
Journal
Toxicology mechanisms and methods
ISSN: 1537-6524
Titre abrégé: Toxicol Mech Methods
Pays: England
ID NLM: 101134521
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
pubmed:
2
3
2019
medline:
19
12
2019
entrez:
2
3
2019
Statut:
ppublish
Résumé
Formulation optimization and antidotal combination therapy are the two important tools to enhance the antidotal protection of the cyanide (CN) antidote dimethyl trisulfide (DMTS). The focus of this study is to demonstrate how the formulation with polysorbate 80 (Poly80), an excipient used in pharmaceutical technology, and the combinations with other CN antidotes having different mechanisms of action enhance the antidotal efficacy of the unformulated (neat) DMTS. The LD
Identifiants
pubmed: 30822191
doi: 10.1080/15376516.2019.1585504
doi:
Substances chimiques
Antidotes
0
Cobamides
0
Excipients
0
Polysorbates
0
Sulfides
0
nitrocobinamide
0
dimethyl trisulfide
3E691T3NL1
Potassium Cyanide
MQD255M2ZO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM