Animal models of closed-skull, repetitive mild traumatic brain injury.
Animal research
Concussion
Mild traumatic brain injury
Neuropathology
Repetitive head impacts
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
2
3
2019
medline:
25
4
2020
entrez:
2
3
2019
Statut:
ppublish
Résumé
The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
Identifiants
pubmed: 30822463
pii: S0163-7258(19)30036-1
doi: 10.1016/j.pharmthera.2019.02.016
pmc: PMC6536340
mid: NIHMS1522723
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-122Subventions
Organisme : NINDS NIH HHS
ID : R01 NS082432
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001072
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002556
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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