DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.

Adult Breast Neoplasms / epidemiology California / epidemiology Child Child Development Child Health Cytochrome P-450 CYP1A1 / genetics DDT / blood DNA Methylation DNA-Binding Proteins / genetics Environmental Pollutants / blood Female Humans Maternal Exposure Maternal-Fetal Exchange Middle Aged Pregnancy Prenatal Exposure Delayed Effects / epidemiology Risk Factors Transcription Factors / genetics
Children cohort DDT DNA methylation Organochlorine Prenatal exposure White blood cells Windows of susceptibility

Journal

Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591

Informations de publication

Date de publication:
03 2020
Historique:
received: 17 09 2018
revised: 07 02 2019
accepted: 25 02 2019
pubmed: 2 3 2019
medline: 29 4 2021
entrez: 2 3 2019
Statut: ppublish

Résumé

Studies measuring dichlorodiphenyltrichloroethane (DDT) exposure during key windows of susceptibility including the intrauterine period suggest that DDT exposure is associated with breast cancer risk. We hypothesized that prenatal DDT exposure is associated with DNA methylation. Using prospective data from 316 daughters in the Child Health and Development Study, we examined the association between prenatal exposure to DDTs and DNA methylation in blood collected in midlife (mean age: 49 years). To identify differentially methylated regions (DMRs) associated with markers of DDTs (p,p'-DDT and the primary metabolite of p,p'-DDT, p,p'-DDE, and o,p'-DDT, the primary constituents of technical DDT), we measured methylation in 30 genes important to breast cancer. We observed DDT DMRs in three genes, CCDC85A, CYP1A1 and ZFPM2, each of which has been previously implicated in pubertal development and breast cancer susceptibility. These findings suggest prenatal DDT exposure may have life-long consequence through alteration in genes relevant to breast cancer.

Identifiants

DOI: 10.1016/j.reprotox.2019.02.010 PMID: 30822522 PMC: PMC6710160
pubmed: 30822522
pii: S0890-6238(18)30531-8
doi: 10.1016/j.reprotox.2019.02.010
pmc: PMC6710160
mid: NIHMS1523128
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
Environmental Pollutants 0
Transcription Factors 0
ZFPM2 protein, human 0
DDT CIW5S16655
CYP1A1 protein, human EC 1.14.14.1
Cytochrome P-450 CYP1A1 EC 1.14.14.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

138-147

Subventions

Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES019457
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Hui-Chen Wu (HC)

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States. Electronic address: hw2057@cumc.columbia.edu.

Barbara A Cohn (BA)

Child Health and Development Studies, Public Health Institute, Berkeley, CA, United States.

Piera M Cirillo (PM)

Child Health and Development Studies, Public Health Institute, Berkeley, CA, United States.

Regina M Santella (RM)

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States.

Mary Beth Terry (MB)

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States; Imprints Center, Columbia University Medical Center, New York, NY, United States; Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, United States.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › États du Sud-Ouest des États-Unis › Californie › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Développement humain › Développement de l'enfant › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Caractéristiques de la population › Santé › Santé de l'enfant › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1A1 › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › DDT › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Échange foetomaternel › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › DDT exposure during pregnancy and DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › DDT exposure during pregnancy and DNA...