Synaptic organizer: Slitrks and type IIa receptor protein tyrosine phosphatases.
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
29
10
2018
revised:
24
01
2019
accepted:
28
01
2019
pubmed:
2
3
2019
medline:
18
2
2020
entrez:
2
3
2019
Statut:
ppublish
Résumé
Slit-like and Trk-like (Slitrk) family members are leucine-rich repeat (LRR)-containing neuronal transmembrane proteins. Slitrks have been highlighted as key synapse organizers at neuronal synapses through interactions with specific members of the presynaptic type IIa receptor protein tyrosine phosphatase (RPTP) family. Recent structural studies on type IIa RPTP/Slitrk1 complexes have unveiled molecular insights into their binding selectivity and have established the role of higher-order receptor clustering in their synaptogenic activity. Here, we will discuss key structural aspects of Slitrk interactions with type IIa RPTP family members, the biological roles of Slitrks in neurons, and our current knowledge of SLITRK mutations in human diseases.
Identifiants
pubmed: 30822649
pii: S0959-440X(18)30155-6
doi: 10.1016/j.sbi.2019.01.010
pii:
doi:
Substances chimiques
Membrane Proteins
0
Protein Tyrosine Phosphatases
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-103Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.