The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models.
Aquatic models
Individuality
Intraspecies variation
Neurobehavioral variation
Zebrafish
Journal
Aquatic toxicology (Amsterdam, Netherlands)
ISSN: 1879-1514
Titre abrégé: Aquat Toxicol
Pays: Netherlands
ID NLM: 8500246
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
28
11
2018
revised:
15
02
2019
accepted:
19
02
2019
pubmed:
2
3
2019
medline:
11
5
2019
entrez:
2
3
2019
Statut:
ppublish
Résumé
Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.
Identifiants
pubmed: 30822702
pii: S0166-445X(18)31049-X
doi: 10.1016/j.aquatox.2019.02.015
pii:
doi:
Substances chimiques
Water Pollutants, Chemical
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-55Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.