Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma.

Cell Line, Tumor Down-Regulation Extracellular Vesicles / metabolism Gene Expression Regulation, Neoplastic Humans Melanoma / genetics Microphthalmia-Associated Transcription Factor / genetics Proto-Oncogene Mas Scavenger Receptors, Class B / genetics Synaptosomal-Associated Protein 25 / genetics Vesicular Transport Proteins / genetics rab GTP-Binding Proteins / genetics
SCARB1 cMET extracellular vesicles melanoma metastasis pigmentation secretory pathway

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
01 Mar 2019
Historique:
received: 13 02 2019
revised: 22 02 2019
accepted: 26 02 2019
entrez: 3 3 2019
pubmed: 3 3 2019
medline: 6 6 2019
Statut: epublish

Résumé

Melanoma is a skin tumor with a high tendency for metastasis and thus is one of the deadliest cancers worldwide. Here, we investigated the expression of the scavenger receptor class B type 1 (SR-BI), a high-density lipoprotein (HDL) receptor, and tested for its role in melanoma pigmentation as well as extracellular vesicle release. We first analyzed the expression of

Identifiants

DOI: 10.3390/ijms20051063 PMID: 30823658 PMC: PMC6429474
pubmed: 30823658
pii: ijms20051063
doi: 10.3390/ijms20051063
pmc: PMC6429474
pii:
doi:

Substances chimiques

MAS1 protein, human 0
MITF protein, human 0
Microphthalmia-Associated Transcription Factor 0
Proto-Oncogene Mas 0
SCARB1 protein, human 0
SNAP25 protein, human 0
Scavenger Receptors, Class B 0
Synaptosomal-Associated Protein 25 0
Vesicular Transport Proteins 0
Vps25 protein, human 0
rab GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund FWF
ID : P 31720
Pays : Austria

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Auteurs

Katharina Kinslechner (K)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. katharina.kinslechner@meduniwien.ac.at.
ORCID: 0000-0001-9944-9999

Birgit Schütz (B)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. birgit.schuetz@meduniwien.ac.at.

Martina Pistek (M)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. martina.pistek@gmx.net.

Philipp Rapolter (P)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. rapolter.philipp@gmx.at.

Hans P Weitzenböck (HP)

Medical and Pharmaceutical Biotechnology, IMC University of Applied Sciences, 3500 Krems, Austria. hans.weitzenboeck@fh-krems.ac.at.

Harald Hundsberger (H)

Medical and Pharmaceutical Biotechnology, IMC University of Applied Sciences, 3500 Krems, Austria. harald.hundsberger@fh-krems.ac.at.

Wolfgang Mikulits (W)

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria. wolfgang.mikulits@meduniwien.ac.at.
ORCID: 0000-0003-4612-7106

Johannes Grillari (J)

Department of Biotechnology, BOKU -University of Natural Resources and Life Sciences, 1190 Vienna, Austria. johannes.grillari@boku.ac.at.

Clemens Röhrl (C)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. clemens.roehrl@meduniwien.ac.at.

Markus Hengstschläger (M)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. markus.hengstschlaeger@meduniwien.ac.at.

Herbert Stangl (H)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. herbert.stangl@meduniwien.ac.at.
ORCID: 0000-0002-7288-7320

Mario Mikula (M)

Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. mario.mikula@meduniwien.ac.at.
ORCID: 0000-0001-5782-0681

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Facteur de transcription associé à la microphtalmie › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Proto-oncogène Mas › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Récepteurs éboueurs › Récepteurs éboueurs de classe B › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › Protéines Q-SNARE › Protéines Qc-SNARE › Protéine SNAP-25 › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Loss of SR-BI Down-Regulates MITF and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › Loss of SR-BI Down-Regulates MITF and...