The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
Alzheimer’s disease diagnosis
Alzheimer’s disease; tau structure; tau aggregation
Amyloid
Tauopathies
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
31
12
2018
accepted:
20
02
2019
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
31
3
2020
Statut:
epublish
Résumé
Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.
Identifiants
pubmed: 30823892
doi: 10.1186/s40478-019-0682-x
pii: 10.1186/s40478-019-0682-x
pmc: PMC6397507
doi:
Substances chimiques
Protein Aggregates
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
31Subventions
Organisme : Agence Nationale de la Recherche
ID : LabEx DISTALZ
Pays : International
Organisme : Agence Nationale de la Recherche
ID : TONIC
Pays : International
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