Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations.
Geant4
Monte Carlo
Proton
RBE
Radiobiological model
Radiotherapy
Survival fraction
Journal
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
08
02
2018
revised:
30
01
2019
accepted:
30
01
2019
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
26
3
2019
Statut:
ppublish
Résumé
The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
Identifiants
pubmed: 30824153
pii: S1120-1797(19)30018-3
doi: 10.1016/j.ejmp.2019.01.018
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-80Informations de copyright
Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.