Production of 8S- and 10S-hydroxy polyunsaturated fatty acids by recombinant Escherichia coli cells expressing mouse arachidonate 8S-lipoxygenase.

Animals Arachidonate Lipoxygenases / genetics Escherichia coli / genetics Fatty Acids, Unsaturated / metabolism Hydrogen-Ion Concentration Mice Recombinant Proteins / genetics Temperature
10S-hydroxy-4,8,12,14,16,19(Z,E,Z,Z,Z,Z)-docosahexaenoic acid 8S-hydroxy-5,9,11,14(Z,E,Z,Z)-eicosatetranoic acid 8S-hydroxy-5,9,11,14,17(Z,E,Z,Z,Z)-eicosapentanoic acid 8S-lipoxygenase Mus musculus

Journal

Biotechnology letters
ISSN: 1573-6776
Titre abrégé: Biotechnol Lett
Pays: Netherlands
ID NLM: 8008051

Informations de publication

Date de publication:
May 2019
Historique:
received: 30 10 2018
accepted: 26 02 2019
pubmed: 3 3 2019
medline: 1 8 2019
entrez: 3 3 2019
Statut: ppublish

Résumé

To quantitatively hydroxylate 8S- and 10S-positions on polyunsaturated fatty acids by recombinant Escherichia coli cells expressing mouse arachidonate 8S-lipoxygenase (8S-LOX). Hydroxylated products gained from the conversion of arachidonic acid (20:4 To the best of our knowledge, this is the first quantitatively biotechnological production of 8S-HETE, 8S-HEPE, and 10S-HDoHE.

Identifiants

DOI: 10.1007/s10529-019-02659-5 PMID: 30825045
pubmed: 30825045
doi: 10.1007/s10529-019-02659-5
pii: 10.1007/s10529-019-02659-5
doi:

Substances chimiques

Fatty Acids, Unsaturated 0
Recombinant Proteins 0
Arachidonate Lipoxygenases EC 1.13.11.-
arachidonate 8-lipoxygenase EC 1.13.11.40

Types de publication

Journal Article

Langues

eng

Pagination

575-582

Subventions

Organisme : Konkuk University
ID : 2018

Auteurs

Kyung-Chul Shin (KC)

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Woo-Ri Kang (WR)

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Min-Ju Seo (MJ)

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Dae Wook Kim (DW)

Forest Plant Industry Department, Baekdudaegan National Arboretum, Bonghwa, 36209, Republic of Korea.

Deok-Kun Oh (DK)

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea. deokkun@konkuk.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Production of 8S- and 10S-hydroxy...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Production of 8S- and 10S-hydroxy...