Synergetic Effect of Silver Nanoparticles and UVC Irradiation on
Genotoxicity
H2AX
Nanoparticles
Silver
Ultraviolet
Journal
Cell journal
ISSN: 2228-5806
Titre abrégé: Cell J
Pays: Iran
ID NLM: 101566618
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
12
03
2018
accepted:
24
06
2018
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
3
3
2019
Statut:
ppublish
Résumé
The use of nanoscale particles, for instance silver nanoparticles (Ag NPs) has considerably increased recently. Since Ag NPs can be transmuted into silver ions; the toxicity and genotoxicity of these NPs along with other external factors such as ultraviolet type C (UVC) irradiation must be evaluated. In the present study, the aim was to investigate the genotoxic effects Ag NPs and UVC co-exposure on human lymphoblastoid TK6 cells. In this experimental study, Ag NPs (~20 nm) were purchased from US Research Nanomaterials Inc. and Results showed that treatment of TK6 cells with different Ag NP concentrations without exposure to UVC can reduce According to our findings, Ag NPs can act to sensitize cells to UVC radiation when used for cancer treatment. So, combination of Ag NPs and UVC irradiation could be used in radiotherapy.
Identifiants
pubmed: 30825294
doi: 10.22074/cellj.2019.5898
pmc: PMC6397600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
204-209Informations de copyright
Copyright© by Royan Institute. All rights reserved.
Déclaration de conflit d'intérêts
There is no conflict of interest in this study.
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